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Additionally, some dogs may be sensitive to legumes even without a known allergy

83 While restriction of fruits and vegetables certainly plays a role in vitamin C deficiency, patients with IBD have been found to have polymorphisms in vitamin C transporter genes and tumor necrosis factor alpha (TNFa), an important inflammatory cytokine in IBD, which downregulates the transcription of vitamin C transporters, further reducing the capacity for vitamin C uptake

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Russo L, Lumeng CN (2018) Properties and functions of adipose tissue macrophages in obesity

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Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability